SHANK3 and autism: We found that theNL3R617W mutation influences the interactions of NL3 with NRXN1,instead of membrane expression or endoplasmic reticulum retention of NL3.Furthermore, the number of synapses and the expression of postsynaptic scaffoldproteins, PSD95 and SHANK3, were found to be decreased in autism associated withNL3R617W mutation.