NLGN3 and autism: The currently known NL3 mutations associatedwith autism include R451C [10], G426S [11], V321A [12], P514S, and R597W [13].Well-validated in in vivo and in vitro models of autism, thesemutations have been found to affect the learning and cognition in mice, reducesynaptic excitability, and produce oxidative stress.