As shown in Figure 4B, in the top 20 pathways, the majority of the DEGs were enriched in pathways closely associated with organic immune and metabolic regulation, such as the intestinal immune network for IgA production, autoimmune thyroid disease, primary immunodeficiency, PPAR signaling pathway, metabolic pathway, fatty acid metabolism and degradation, and ascorbate and aldarate metabolism (Figure 4B). The gene discussed is PPARA; the disease is inborn error of immunity.