Astaxanthin was associated with a higher quantity of tumor‐associated macrophages, infiltration of CD8+ T cells, Tumor Granzyme B, IL‐2, serum TNF‐α and interferon‐γ, genetic transcription of CXCL9, CXCL10, and CXCR3, and mRNA expression of cluster of differentiation 40. The gene discussed is TNF; the disease is neoplasm.