Furthermore, they found that lycopene may have a preventive effect on NAFLD by inhibiting nucleotide‐binding domain, leucine‐rich–containing family, pyrin domain–containing‐3 (NLRP3), Pro‐Caspase‐1, Caspase‐1, NF‐κB, and TLR‐4 expression. This evidence concerns the gene TLR4 and metabolic dysfunction-associated steatotic liver disease.