Therefore, LPS triggers systemic and local inflammation in the body that enhances liver injury and the degree of obesity by elevating pro‐inflammatory cytokine levels such as interleukin (IL)‐6, IL‐1, and tumor necrosis factor α (TNF‐α) (Cani et al. 2008; Roh and Seki 2013; You et al. 2005). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.