Also, it has the potential to enhance silent information regulator sirtuin 1 (SIRT1) activity and nicotinamide phosphoribosyltransferase (NAMPT) expression, as well as regulate the expression of genes related to circadian rhythms, which control the inflammation related to obesity and the development of cancer associated with metabolic syndrome. The gene discussed is SIRT1; the disease is obesity due to melanocortin 4 receptor deficiency.