Astaxanthin was associated with a higher quantity of tumor‐associated macrophages, infiltration of CD8+ T cells, Tumor Granzyme B, IL‐2, serum TNF‐α and interferon‐γ, genetic transcription of CXCL9, CXCL10, and CXCR3, and mRNA expression of cluster of differentiation 40. This evidence concerns the gene IL2 and neoplasm.