In addition, iron plays an important role in the pathogenesis of AD by regulating the phosphorylation of the Ser637 site of Dynamin-related protein 1 (Drp1), which consists of several structural domains, including the GTPase domain, the intermediate domain, and the GTPase Effector Domain (GED) (Park et al., 2015; Kandimalla et al., 2016). This evidence concerns the gene DNM1L and Alzheimer disease.