The results indicate a significantly improved OS in the LT+TKI+ICI group compared to the LT+TKI group for patients with the following characteristics: age >50, male, ALT >40u/ml, ALBI grade 1, Child-Pugh score class A, PIVKA-II ≤ 1000 mAu/ml, number of tumors ≤3, size of tumor ≤10cm, vascular invasion, no intrahepatic metastasis, no lymphatic metastasis, no extrahepatic metastasis, no cirrhosis, and HBV infection (Figure 2A). This evidence concerns the gene GPT and neoplasm.