In a prospective cohort of 229 biopsy-naïve men (median PSA=1.26 ng/ml), opportunistic bpMRI screening detected clinically significant PCa (csPCa) in 9.2% of participants, 38.1% of which would have been missed by PSA/DRE-based criteria (25). Here, KLK3 is linked to posterior cortical atrophy.