SATB1 and colorectal carcinoma: Subsequent studies have consistently confirmed that SATB1 is overexpressed in CRC samples relative to adjacent non-malignant tissues (32, 38, 111–115, 147, 148), with its overexpression associated with deeper tumor infiltration, lymph node metastasis, poor differentiation, and advanced TNM stages (32, 38, 110–112, 114, 115).