Subsequent studies have consistently confirmed that SATB1 is overexpressed in CRC samples relative to adjacent non-malignant tissues (32, 38, 111–115, 147, 148), with its overexpression associated with deeper tumor infiltration, lymph node metastasis, poor differentiation, and advanced TNM stages (32, 38, 110–112, 114, 115). Here, SATB1 is linked to neoplasm.