Additionally, SATB1 knockdown in NSCLC cells downregulates tumor-promoting genes like c-myc, MMP2, MMP9, S100A4, and VEGF-B while also reducing the expression of EMT-related genes (e.g., N-cadherin, fibronectin) and inhibiting the Wnt/β-catenin pathway. The gene discussed is SATB1; the disease is non-small cell lung carcinoma.