Studies have confirmed that CENP-H is overexpressed in renal cell carcinoma (RCC), GC, hypopharyngeal squamous cell carcinoma, nasopharyngeal carcinoma, endometrial carcinoma (EC), lung cancer (LC), cervical cancer, esophageal cancer (ESCA), liver cancer, colorectal cancer (CRC), oral squamous cell carcinoma (OSCC), breast cancer (BC), and tongue cancer. This evidence concerns the gene CENPH and laryngotracheoesophageal cleft.