Others found an increase in sterol regulatory element binding transcription factor (Srebp1c, a NAD dependent deacetylase), the main transcription factor for proteins involved in synthesizing fatty acids, fatty acid synthase (FAS), and Acetyl Co-A carboxylase in the NAFLD/sedentary group (Carbajo-Pescador et al., 2019[21]; Ghareghani et al., 2018[41]; Guo et al., 2020[47]; Linden et al., 2014[87], 2015[88]; Martinez et al., 2018[96]; Munoz et al., 2018[103]; Pereira et al., 2019[117]; Piguet et al., 2015[121]; Rector et al., 2011[126]). This evidence concerns the gene FAS and metabolic dysfunction-associated steatotic liver disease.