By enhancing the interaction between AMPK and ULK1, SQSTM1 promotes ULK1 phosphorylation, induces autophagy in response to fatty liver toxicity, and activates the Keap1-Nrf2 signaling pathway, offering protection from lipotoxicity (Lee et al., 2020[83]). This evidence concerns the gene ULK1 and Hepatic steatosis.