The genes coding for molecules involved in mitochondrial bioenergetics, namely mitochondrial transcription factor A (Tfam), peroxisome proliferator-activated receptor alpha (PGC1-alpha), nuclear respiratory factor 1 (NRF1), mitochondrial transcription factors Tfb1m and Tfb2m, had different expression between the NAFLD/exercise vs NAFLD/ sedentary (Khoo et al., 2020[73]). Here, PPARA is linked to metabolic dysfunction-associated steatotic liver disease.