CD274 and Sepsis: In a subsequent analysis of the differential expression of immune checkpoint genes between the sepsis and control groups using microarray data (Figure 6B), we found that MAPK3 had a significant negative association with LAG3 (r = −0.67, P < 0.001), PDCD1 (r = −0.45, p = 0.036), and TIGIT (r = −0.73, p < 0.001), but a positive association with CD274 (r = 0.46, p = 0.031).