GLI Family Zinc Finger 2 (GLI2) is a key regulator in the Hedgehog (Hh) signaling pathway, which plays an important role in tissue development during embryogenesis and is thought to promote liver regeneration (Omenetti et al., 2011), Sun et al. found that GLI2 exacerbates sepsis-related liver injury by regulating the expression of synovial apoptosis inhibitor 1 (SYVN1), which inhibits PPARα-mediated autophagy (Sun et al., 2024). The gene discussed is GLI2; the disease is Sepsis.