There are few studies on ferritinophagy and sepsis-associated liver injury, but based on literature review, I believe the following targets may be related to ferritinophagy: GPR116, an adhesion G protein-coupled receptor (GPCR), can inhibit key ferroptosis targets such as system Xc, GSH, and GPX4, inducing sepsis-related liver injury (Yan et al., 2014). This evidence concerns the gene GPX4 and Sepsis.