In a study on A. muciniphila and HCC, dysbiotic animals with HCC exhibited an intrahepatic immunosuppressive microenvironment characterized by intestinal barrier damage, bacterial translocation-induced monocyte myeloid-derived suppressor cell (MDSC) expansion, and inhibition of CD4+T and CD8+T cells, but they were reversed upon treatment of animals with A. muciniphila. The gene discussed is CD4; the disease is hepatocellular carcinoma.