Volcano analysis showed that several inflammation-related genes (STAT1, CXCL9, CXCL11, IRF1 etc.)were upregulated in SLE over non-autoimmune control follicles, while IL4-related (IL4R, FCER2) and cellular oxidation-related (TXNIP) genes were upregulated in control follicles (Figure 1B). The gene discussed is IRF1; the disease is systemic lupus erythematosus.