Cell proliferation requires a doubling of energy and cell biomass, and replicating cells are thus particularly sensitive to deficiencies in oxidative phosphorylation (OXPHOS), and OXPHOS-deficient replicating cells are especially vulnerable to high levels of Myc, as MYC helps them evade metabolic checkpoints and accelerate cell cycle progression; (3) Pathways related to mitochondrial diseases, as upregulation of Myc and/or its typical transcriptional features have been observed in several cellular and mouse models of mitochondrial diseases. Here, MYC is linked to mitochondrial disease.