A core set of 10 key DEGs was selected through further bioinformatics analyses that included IL15, CCL4, FLNA, CCL5, IL7, VCAM1, SYK, ACTN1, CCL20, and IL1R1, with a majority of these genes being significantly overexpressed in CLL relative to DLBCL. The gene discussed is ACTN1; the disease is diffuse large B-cell lymphoma.