This is related to the fact that γδ T cells recognize antigen in a non-MHC-restricted manner and that γδ T cells provide an early source of IFN-γ in the tumor microenvironment, γδ T cells can enhance the function of CD4+, CD8+ T cells, mature dendritic cells and activate neutrophils (123–125). This evidence concerns the gene CD4 and neoplasm.