The migration of effector CD8 T cells in the TME depends on the chemokine receptor CXCR3 and its ligands, CXCL9 and CXCL10, which are predominantly expressed by Th1-related, IFN-γ-activated macrophages, cancer-associated fibroblasts (CAFs), and tumor cells (24). This evidence concerns the gene CD8A and neoplasm.