Researchers sorted and cultured Vγ9Vδ2T cells from healthy human peripheral blood PBMCs and co-cultured them with cholangiocarcinoma cell lines, and showed that Vγ9Vδ2T cells could mediate cholangiocarcinoma apoptosis via lysosome-associated membrane protein (LAMP-1), suggesting that Vγ9Vδ2T cells may be useful in facilitating the development of new strategies for adoptive immunotherapy of cholangiocarcinoma (121, 122). This evidence concerns the gene LAMP1 and cholangiocarcinoma.