Research also indicates that late recurrence patients with ICC have higher levels of regulatory T cell infiltration in the TME and lower CD8+ T cell infiltration compared to early recurrence patients (86).Moreover, the expression levels of T cell chemokines, such as CXCL9, CXCL10, and CXCL11, are lower in the TME of late recurrence patients (86). This evidence concerns the gene CD8A and intrahepatic cholangiocarcinoma.