Strikingly, all mice immunized with this peptide had high levels of anti-dsDNA autoantibodies, a hallmark of systemic lupus erythematosus (SLE) (15): They were also highly positive for La/SSB antigen (Table 1), a 47-kDa protein involved with small RNAs synthesized by RNA polymerase II, typically seen in Sjogren’s syndrome and SLE patients (16). The gene discussed is SSB; the disease is systemic lupus erythematosus.