In our previous study (Zhang et al.2022), we discovered that after ZIKV infection, cellular vimentin filaments gradually aggregate in the perinuclear region to form a cage-like structure that encapsulates the viral replication factory, converges important host factors and viral components, and interacts with a variety of endoplasmic reticulum proteins, including ribosome-binding protein 1 (RRBP1), to facilitate viral RNA replication. Here, VIM is linked to Zika virus infectious disease.