Moreover, multivariate Cox regression analysis suggested that high PNI was consistently related to decreased renal risk (HR, 0.664; 95% CI, 0.443–0.994; p = 0.047) after adjustment for age, gender, hypertension, e-GFR, urine protein more than 1 g per day, anemia, serum albumin concentration less than 30 grams per liter and the Oxford MEST-C score (Table 2). The gene discussed is ALB; the disease is anemia.