In addition to Medical Subject Headings (MeSH) terms, the following keywords were utilised to find relevant articles: "nemolizumab," "prurigo nodularis," "chronic pruritus," "IL-31 receptor," "IL-31 antagonist," "anti-IL-31 receptor α antibody," "chronic itch," and "nodular prurigo." In order to find more qualifying publications, we also looked through the reference lists of the included research and pertinent reviews. This evidence concerns the gene IL31 and prurigo nodularis.