Of the total 118 plasma metabolites associated with CXCL6 or male infertility, androstenediol (3beta,17beta) monosulfate (2) levels, sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2) levels, sphingomyelin (d18:1/20:1, d18:2/20:0) levels, arachidonoylcholine levels, X-12822 levels, and phosphate to glycerol ratio appeared in both groups. Here, CXCL6 is linked to male infertility.