Alisol A was shown to lead to neurovascular protection in cerebral ischemic mice through the activation of the AKT/GSK3β signaling pathway; the compound attenuated the neurological deficits and cognitive deficits and inhibited IL-6 and IL-1β expression, in addition to promoting neuronal survival (Li et al., 2023). This evidence concerns the gene AKT1 and Cognitive impairment.