One study investigating the association between migraine incidence and CYP2C19 phenotypes stated that male patients with decreased CYP2C19 activity (*2, *3, *8, *9) are at a higher risk of experiencing PPIs-related migraine (OR, 2.11; 95% CI, 1.04–4.29; p = 0.038) compared to men with other phenotypes and females (Pisanu et al., 2021). The gene discussed is CYP2C19; the disease is migraine disorder.