Furthermore, Cao et al. (2021a) found that reduced miR-214 stimulates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway and aggravates osteoarthritis progression through targeting inhibitory kappa B kinase subunit beta (IKKβ) with subsequent progression of clinical signs and symptoms of OA regarding joint pain, swelling, limited range of motion. Here, IKBKB is linked to osteoarthritis.