14-3-3 proteins are highly expressed in the central nervous system, making up about 1% of all soluble proteins.12 14-3-3ζ and 14-3-3γ were found to be most abundantly expressed in the brain.13,14 14-3-3 proteins were reported to play an important role in neurodegenerative diseases, by binding and thereby modulating several proteins that aggregate in these diseases.15 This chaperone-like function of 14-3-3 has been reported16 for the microtubule-associated protein Tau, a key protein in Alzheimer's disease (AD) and frontotemporal dementia. Here, YWHAQ is linked to early-onset autosomal dominant Alzheimer disease.