Advanced degrees of ischemia, infection, and the extent of ischemic lesions in patients with diabetes (graded with the Wound, Ischemia, and Foot Infection [WIfI] classification) are associated with amputations, increased mortality, and increased arterial stiffness.2,3 Serological markers such as C-reactive protein and interleukin-6 have been associated with increased mortality in patients with chronic limb-threatening ischemia (CLTI).4 Measures of the pressure in the ischemic limb, primarily the ankle/brachial index (ABI), are some of the most widely adopted markers of PAD and CLTI. This evidence concerns the gene IL6 and ischemia.