Dysregulation or mutation of BMPs and/or their downstream signaling molecules may lead to various bone disorders such as BDA2 (brachydactyly type A2 and FOP (fibrodysplasia ossificans progressiva.11, 12, 13 It is important to note that not all BMPs exhibit osteo-inductive properties. Here, CLN5 is linked to fibrodysplasia ossificans progressiva.