To explore TAM heterogeneity in NB, TAMs were isolated from 31 NB patients, yielding a total of 8762 TAMs classified into six clusters, annotated as FCN1+, APOD+, SPP1+, IGHM+, CCL5+, and STMN2+ TAMs (Fig. 4A, B). Here, SPP1 is linked to neuroblastoma.