,32 In their research, Lan et al33 observed that acute cerebral ischemia triggers neuronal ferroptosis, and the administration of Naotaifang to rats with middle cerebral artery occlusion resulted in the suppression of ferroptosis through activation of the TFR1 (transferrin receptor 1)/DMT1 (divalent metal transporter 1) and SCL7A11/GPX4 pathways. Here, TFRC is linked to brain ischemia.