Solasonine participates in ferroptosis by inhibiting the transcriptional up-regulation of OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1) mediated by TFAP2A (transcription factor AP-2 alpha), which in turn activates the ubiquitination-mediated degradation of SLC7A11 and encourages ferroptosis in pancreatic cancer cells. Here, SLC7A11 is linked to pancreatic neoplasm.