PCLS models effectively capture the interplay between genetic and environmental factors, as demonstrated by the expression of genes involved in both T2 and non-T2 asthma pathogenesis, along with cytokines associated with these phenotypes, such as IL-25, TSLP, the TTP family and IL-13, in lung sections from asthmatic patients (Refs 36, 37, 38). Here, IL13 is linked to asthma.