In gastric cancer cells harbouring p53 mutations, ovarian tumour domain‐containing 5 (OTUD5) transcription is upregulated due to the inactivation of p53, allowing OTUD5 to stabilise glutathione peroxidase 4 (GPX4) protein, inhibit ferroptosis and thereby promoting gastric cancer progression. Here, OTUD5 is linked to gastric cancer.