p53 can also induce ferroptosis in tumour cells through the GPX4‐independent enzyme ALOX12.22 Furthermore, p53 has been shown to upregulate the expression of YAP1 and SAT1, enhance ACSL4 expression and augment ALOX15 enzyme activity, thereby increasing the production of LPOs.23, 24. This evidence concerns the gene TP53 and neoplasm.