Obesity and AT dysfunction have a negative impact on the key pathogenetic factors for the development of type 2 diabetes: impaired insulin sensitivity and insulin secretion, hepatic steatosis and insulin resistance, increased diabetogenic signals from AT (adipokines, lipids, pro‐inflammatory cytokines), reduced diversity of gut microbiota and impaired skeletal muscle insulin sensitivity.4, 9, 10, 64, 65, 66, 117, 118. The gene discussed is INS; the disease is type 2 diabetes mellitus.