To elucidate the role of XAB2 in CRC, we used siRNAs to knockdown XAB2 in CRC cells (HCT116 and SW480) with higher basal XAB2 expression and overexpressed XAB2 in CRC cells (HT29 and RKO) with lower basal expression. Here, XAB2 is linked to colorectal carcinoma.