The idea that high apoptotic indexes and PS externalization on apoptotic cells contribute as a cell intrinsic signal to immune evasion is supported by recent evidence that Xkr8 knockdown on cancer cells, which prevents PS externalization during caspase-mediated apoptosis, enhances chemotherapy efficacy and stimulates immune host anti-tumor immunity in both subcutaneous and orthotopic pancreatic solid tumor models [154]. This evidence concerns the gene XKR8 and neoplasm.