ANO6 and neoplasm: As noted above, discovery of a calcium-activated PS scramblase activation platform clearly links cell stress and the ensuing PS externalization with a classic tumor signal related to the dysregulation of intracellular calcium and hypercalcemia (Fig. 7A. Indeed, TMEM16F, a PS scramblase, is activated by influx of calcium into the cytosol [102, 159, 160].