For instance, EVs from BC cells can activate fibroblasts and promote their invasive behavior through the transfer of some microRNAs such as microRNA-125-b [57], miR-146a [58], miR-652-5p, miR-126, and miR-185-5p [45] or via survivin [59] and TGF-β/Smad signaling pathway [60]. This evidence concerns the gene BIRC5 and breast cancer.