In a recently published mouse study, Pietrasanta et al. demonstrated that antenatal antibiotic exposure increases susceptibility to late onset sepsis, and is associated with lower maternal BM IgA, neonatal fecal IgA, and IgA coating of intestinal bacteria, leading to systemic translocation of intestinal bacteria.13 Weaned mice born to antibiotic-treated mothers had reduced intestinal IgA+ plasma cells, fecal secretory IgA, colonic regulatory T cells (Tregs) and Th17 cells, and reduced fecal microbial diversity. Here, CD79A is linked to Sepsis.