STK11 and non-small cell lung carcinoma: The Shackleford group performed in vivo therapeutic studies with MLN0128 using NSCLC models initiated by a conditionally activated K-ras oncogene (LKB1-proficient KLUC mice) and combined with LKB1 deletion in mice also bearing floxed alleles of LKB1 (KLLUC mice), in which lung cancers are induced by intranasal administration of Adeno-Cre21.