CASS4 and Alzheimer disease: For instance, the presence of one or two alleles of the rs429358 SNPs, which was highlighted among the highly ranked features by the Gini index, was found to increase the AD risk, while the presence of one or two alleles of the CASS4 gene34 or the MS4A6A35 gene related SNPs was associated with a smaller chance of MCI or AD (as shown in the Supplementary material).