Gini importance was the only method able to highlight important SNPs features, including rs429358, which is located in the ApoE and is reported to be associated with a higher AD risk32, rs6448453, which is associated with the CLNK gene and has been shown to increase the risk of developing AD33, as well as rs2081545 of the MS4A6A gene, which is proven to be linked to the studied diseases according to the literature. Here, APOE is linked to Alzheimer disease.