HSPA1A and Familial prostate cancer: In 2009, some antibodies were found to directly bind eGRP78 COOH-terminal domain, further inhibiting cellular proliferation and promoting apoptosis of 1-LN and DU145 prostate cancer cell lines.578 Besides, HSP70 in the membrane of exosomes can interact with the toll-like receptor 2 (TLR2), involved in tumor development.