NOS3 and heart disorder: Cardiovascular disease (CVD) is a collective term that includes heart and vascular diseases, including hypertension, atherosclerosis, and cardiac fibrosis.332 Among these factors, arterial hypertension is linked to dysfunction of nitric oxide (NO), which is one of the main factors in keeping normal blood pressure.333 Numerous client proteins of HSP90, such as endothelial nitric oxide synthase (eNOS) that produces NO and participates in the relaxation of vascular smooth muscle, have been reported in known pathways involved in heart disease.