HSP90AA1 and Spinocerebellar ataxia type 3: An in vitro study suggested that HSP90 protects against α-synuclein oligomer accumulation via its rapid transformation into fibrils, further preventing the formation of toxic α-synuclein.327 Spinocerebellar ataxia type 3 (SCA3) is a type of inherited neurological disease resulting from the expansion of polyglutamine (polyQ) via pathological mechanisms and is clinically characterized by peripheral neuropathy and cognitive disturbances.328,329 The expanded polyQ may destabilize many proteins, causing them to misfold and aggregate.