HSPA8 and cancer: Apoptozole was assessed to induce the death of some cancer cells, such as SK-OV-3, HCT-15, and A549.555 Subsequently, the compound was identified to bind to NBD of HSP70i and HSC70 and inhibit ATPase activity, without binding to other HSPs.556 The studies in vivo showed that apoptozole led to 61% volume reductions of the A549 xenografts, compared with the vehicle-treated group.557 While apoptozole has demonstrated antitumor efficacy in animal models, its potential toxicity and long-term safety in normal tissues remain incompletely elucidated.