Besides, HSP90 regulates many pathways, including the MAPK, PI3K/AKT/mTOR, and tumor necrosis factor-alpha (TNF-α) signaling pathways, which regulate cardiovascular diseases via different pathological processes.334 In addition to the effect of HSP90, the highly complicated effect of HSP70 on CVD development is under discussion. This evidence concerns the gene TNF and cardiovascular disorder.