HSPA8 and cancer: Importantly, HS-72 not only showed potent anti-proliferative activity against the tumorigenic breast lines, but also reduced tumor growth in vivo.558 Besides, subsequently studies exhibited that HS-72 could inhibit dengue virus infection, highlighting the potential of HSP70i as an antiviral target.559 Due to constitutive expression of HSC70 within the cell, depletion of HSC70 significantly reduces proliferation, migration and invasion, and promotes apoptosis of cancer cells.560 Inhibiting HSC70 was also believed as an effective strategy of anti-cancers.