Capsaicin, a natural product, was discovered to bind the N-terminus of HSP90, enhancing the anti-tumor effects of 17-AAG.440 Besides, novel tropane analogs derived from XL888 displayed significant HSP90 inhibitory activity with IC50 of 57 nM.441 Collectively, these findings support that novel chemical scaffolds might be used to design new HSP90 N-terminus inhibitors. This evidence concerns the gene HSP90AA1 and neoplasm.