HSP90AB1 and cancer: In mouse models, HH01 potently inhibited the tumor growth of pancreatic ductal adenocarcinoma cell xenografts.505 The development of antibody therapeutics to inhibit eHSP90 provides a potential method against cancer.506 Mechanically, the inhibition of eHSP90 can avoid inducing HSR and intracellular HSP90-dependent client degradation.