And mechanistic studies revealed that TPP-apoptozole inhibits the GRP75-p53 interaction and induces mitochondrial outer membrane permeabilization, consequently leading to mitochondria-mediated apoptosis.575 Recently, a chlorpromazine derivative was also reported to exhibit inhibitory activity against endometrial Cancer through directly targeting GRP75.576 Although the initial findings highlight the potential of GRP75 as direct therapeutic target, more studies still are necessary to design inhibitors with high activity and selectivity. The gene discussed is HSPA9; the disease is endometrial cancer.