MAPT and Alzheimer disease: Chen et al. suggested that the neurotoxicity induced by Aβ can be mitigated through the use of HSP90 inhibitors.325 In addition, hyperphosphorylated tau is associated with the cognitive decline in patients with AD and similar tauopathies, and the hyperactivation of tau kinases is thought to contribute to tau pathogenesis.326 HSP90 inhibition greatly reduces the activity of tau and causes a decrease in phosphorylated tau.