Apart from the seven categories of diseases listed above, HSPs are involved in regulating many other diseases, including ocular diseases, liver diseases and skin diseases.15 The retina is a complex, metabolically demanding and often stressed eye component.374 HSP90 is widely distributed throughout the retina and plays multiple roles in the folding, activation and assembly of many proteins.375 Uveal melanoma (UM) is the most frequent early intraocular malignancy in adults. The gene discussed is HSP90AA1; the disease is liver disorder.