Activated PGC-1α triggers mitochondria and induces fatty acid oxidative processes, which reduce the accumulation of free fatty acids and reduce insulin resistance.348 Overall, the complicated role of HSP70 in T2DM is closely associated with insulin resistance pathogenesis, suggesting that HSP70 has vital therapeutic potential in the management of T2DM. Here, HSPA1A is linked to type 2 diabetes mellitus.