IL1B and osteoarthritis: To elucidate the biological processes of inflammation in osteoarthritis, an in vitro inflammatory model was established via subjecting the cultured primary chondrocytes to interleukin-1β (IL-1β), the most approved approach to mimic the process of inflammation.11 RNA-seq was performed on chondrocytes under IL-1β stimulation for 0/6/48 h, with 6 h considered as times point for rapid response and 48 h for long-term response.