Additionally, several studies in cancer have suggested that PI3K-Akt signaling improves the transcriptional activity of NF-κB TFs, promoting and supporting the growth of tumors, as well as contributing to the development of multidrug-resistance.34 Hence the intervention of PI3K-Akt signaling by controlling ZBTB20 represents a promising therapeutic strategy for cancer treatment. This evidence concerns the gene NFKB1 and cancer.