These non-leukemic T cells establish connections with LGLL leukemia cells through costimulatory cell–cell interactions, pro-inflammatory cytokines secreted by monocytes, and IFNγ secreted by T-LGLL clones.15 Therefore, by delving into the immunological mechanisms of LGLL, we can design more effective and better-tolerated drug regimens and clinical treatment regimens. The gene discussed is IFNG; the disease is T-cell large granular lymphocyte leukemia.