P2RX7, a ligand‐gated ion channel that is abundantly expressed in macrophages, plays a pivotal role in the initiation and progression of inflammatory and autoimmune disorders.[37] Here, utilizing the miRanda database and luciferase reporter assays, we identified P2RX7, which has been documented to be upregulated in PBMCs of SS dry eye patients,[38] was a novel target of miR‐31‐5p in macrophages. This evidence concerns the gene P2RX7 and dry eye syndrome.