In this study, we demonstrated that FTO‐regulated miR‐31‐5p, significantly downregulated in peripheral blood mononuclear cells (PBMCs) of SS dry eye patients and in LGs of rabbit autoimmune dacryoadenitis, an animal model of autoimmune dry eye which can closely mimic human SS dry eye disease,[28, 29] was critical for autoimmune dry eye progression. Here, FTO is linked to Keratoconjunctivitis sicca.