TRAF3IP3 and central nervous system cancer: For instance, TRAF3IP3 could facilitate glioma cell proliferation, migration, and invasion, at least partly by activating the ERK signaling pathway.[5] In addition, TRAF3IP3‐shRNA in melanoma tumors showed an increase in apoptosis and a decrease in microvascular density, which supported a proangiogenic and a direct protumoral role in melanoma.[31] However, the exact role of TRAF3IP3 in tumors depends on the cancer type or context.