TRAF3IP3 and central nervous system cancer: reported that TRAF3IP3 levels were substantially increased in the vasculature of breast cancer tissues and melanoma cells, suggesting its significant role in proangiogenesis and carcinogenesis.[8] Moreover, TRAF3IP3 can promote glioma cell proliferation, migration, and invasion, and elevated TRAF3IP3 expression may serve as a potential biomarker for glioma prognosis.[9] As to LUAD, the TRAF3IP3 expression profile or its role in LUAD proliferation and patient prognosis has not been investigated.