TRAF3IP3 and cancer: The selective clearance of ER subdomains is involved in controlling ER size and activity during ER stress, restoring ER homeostasis after ER stress is resolved, and removing parts of the ER where aberrant and potentially cytotoxic material has segregated.[17, 36] We examined whether the autophagic flux induced by TRAF3IP3 could result in cancer cell death or have a protective effect.