Autophagy can be activated upon ER stress to restore homeostasis in various cancer cells.[13, 19, 27] To explore whether the autophagy induced by TRAF3IP3 was caused by the ER stress‐regulated PERK/ATF4/CHOP pathway, we used the TRAF3IP3‐overexpression A549 and PC9 cell lines for the experiments. The gene discussed is ATF4; the disease is cancer.