We then developed a mouse Pak2ctg model with inducible cardiac‐specific overexpression of wild type Pak2 driven by Myh6‐creERT (Figure S1, Supporting Information) to explore effects of Pak2 overexpression on acute isoproterenol or TAC‐induced ventricular arrhythmias (Figure 3; Figure S5, Supporting Information). The gene discussed is MYH6; the disease is Ventricular arrhythmia.