The results of Toshiki’s team showed that HRW downregulated the gene expression of Fancc which is considered an oxidative stress responsive gene, and it was suggested that the downregulation of Fancc reflected decreased gingival oxidative stress.[95] In the future, it is expected that more detailed genetic mechanism will be clarified and therapy for periodontitis, gingivitis and other oral diseases can target the exact pathway of inflammation. This evidence concerns the gene FANCC and gingivitis.