Celiac disease pathology involves the activation of CD4+ T-lymphocytes, B cell expansion, and CD8+ T-lymphocytes.[62] Immunosuppression, both locally within tumors and systemically, is common in GBM, leading to dysfunction in tumor-induced T cells and NK cells, as well as expansion of regulatory T cells and myeloid-derived suppressor cells. Here, CD4 is linked to glioblastoma.