At the same time, studies have shown that processes such as brain tissue necrosis and repair after trauma involve the massive release of IL-1β, TNF-α, and other inflammatory factors.[20–22] These biomolecules play an important role in the secondary injury of TBI, especially in the formation of brain edema after TBI, and may be used as biomarkers to evaluate the severity of trauma and even the prognosis.[23] Therefore, the role of these biomarkers (IL-1β and NFL) in the treatment of sTBI deserves further exploration. This evidence concerns the gene IL1B and brain edema.