Phenylalanine is known to be an essential amino acid that enhances immune response and inflammation.[52] Recent study has indicated that phenylalanine promotes alveolar macrophage pyroptosis and release pro-inflammatory factors (IL-1β and IL-18), which aggravates lung injury and ARDS death in mice, suggesting phenylalanine may be a promising target for ARDS therapy.[53] In addition, drug prediction revealed strong associations of chlorzoxazone, ajmaline, and clindamycin with multiple diagnostic genes. This evidence concerns the gene IL18 and acute respiratory distress syndrome.