IGF-1 has been associated with PCa in prior research; however, its specificity remains limited.[23] LPA is a type of lipoprotein that is inherently associated with various cancers, including PCa.[24] Multiple MR studies have also uncovered a potential association between LPA and PCa.[25,26] Nevertheless, further investigation is required to explore the relationship between BUB and PCa. This evidence concerns the gene IGF1 and cancer.