Pemphigus is a chronic inflammatory skin disease caused by autoimmunity.[13] We aimed to retrospectively evaluate the relationship between the disease activity and IGC, IG%, anti-Dsg1, anti-Dsg3, CRP levels, neutrophil-to-lymphocyte ratios (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with pemphigus. The gene discussed is CRP; the disease is pemphigus.