IFNG and ocular melanoma: Notably, genetic variants at Bax gene G(-248), interferon-gamma, interleukin-1beta, and toll-like receptor 2 have been identified as associated with heightened susceptibility to hematogenous or traumatic OM.[5–7] Meanwhile, the identification of the cyclooxygenase-2 enzyme has implicated a potential association with an elevated susceptibility to post-traumatic OM in individuals of Chinese descent.[8]